Monoamine oxidase inhibitors (MAOIs, such as linezolid, phenelzine, etc), increase the risk of serotonin syndrome, a mild to a life-threatening build-up of serotonin in the system. A combination of MAOIs with escitalopram could lead to a spike in blood pressure, sudden rise in body temperature or severe seizures. Similarly, escitalopram can interact with other agents that affect serotonin in the brain, such as tricyclic antidepressants, certain pain medications, supplements that contain St. John's Wort or tryptophan. Be prepared to share all prescription and over-the-counter medications, as well as any other products you take, with your provider. Seek medical advice before combining any drugs with escitalopram treatment.